Descriptive Epidemiology, Clinical Characteristics and Outcomes for Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Infected Patients in AlAin – Abu Dhabi Emirate
Identifieur interne : 000608 ( Pmc/Corpus ); précédent : 000607; suivant : 000609Descriptive Epidemiology, Clinical Characteristics and Outcomes for Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Infected Patients in AlAin – Abu Dhabi Emirate
Auteurs : F. Alkendi ; S. Chandrasekhar Nair ; R. HashmeySource :
- Journal of Infection and Public Health [ 1876-0341 ] ; 2019.
Url:
DOI: 10.1016/j.jiph.2018.10.099
PubMed: NONE
PubMed Central: 7128491
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Descriptive Epidemiology, Clinical Characteristics and Outcomes for Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Infected Patients in AlAin – Abu Dhabi Emirate</title><author><name sortKey="Alkendi, F" sort="Alkendi, F" uniqKey="Alkendi F" first="F." last="Alkendi">F. Alkendi</name></author><author><name sortKey="Nair, S Chandrasekhar" sort="Nair, S Chandrasekhar" uniqKey="Nair S" first="S. Chandrasekhar" last="Nair">S. Chandrasekhar Nair</name></author><author><name sortKey="Hashmey, R" sort="Hashmey, R" uniqKey="Hashmey R" first="R." last="Hashmey">R. Hashmey</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmc">7128491</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7128491</idno><idno type="RBID">PMC:7128491</idno><idno type="doi">10.1016/j.jiph.2018.10.099</idno><idno type="pmid">NONE</idno><date when="2019">2019</date><idno type="wicri:Area/Pmc/Corpus">000608</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000608</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Descriptive Epidemiology, Clinical Characteristics and Outcomes for Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Infected Patients in AlAin – Abu Dhabi Emirate</title><author><name sortKey="Alkendi, F" sort="Alkendi, F" uniqKey="Alkendi F" first="F." last="Alkendi">F. Alkendi</name></author><author><name sortKey="Nair, S Chandrasekhar" sort="Nair, S Chandrasekhar" uniqKey="Nair S" first="S. Chandrasekhar" last="Nair">S. Chandrasekhar Nair</name></author><author><name sortKey="Hashmey, R" sort="Hashmey, R" uniqKey="Hashmey R" first="R." last="Hashmey">R. Hashmey</name></author></analytic><series><title level="j">Journal of Infection and Public Health</title><idno type="ISSN">1876-0341</idno><idno type="eISSN">1876-035X</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader></TEI><pmc article-type="abstract"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Infect Public Health</journal-id><journal-id journal-id-type="iso-abbrev">J Infect Public Health</journal-id><journal-title-group><journal-title>Journal of Infection and Public Health</journal-title></journal-title-group><issn pub-type="ppub">1876-0341</issn><issn pub-type="epub">1876-035X</issn><publisher><publisher-name>Published by Elsevier Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmc">7128491</article-id><article-id pub-id-type="publisher-id">S1876-0341(18)30269-7</article-id><article-id pub-id-type="doi">10.1016/j.jiph.2018.10.099</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Descriptive Epidemiology, Clinical Characteristics and Outcomes for Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Infected Patients in AlAin – Abu Dhabi Emirate</article-title></title-group><contrib-group><contrib contrib-type="author" id="aut0005"><name><surname>Alkendi</surname><given-names>F.</given-names></name><xref rid="cor0005" ref-type="corresp">⁎</xref></contrib><contrib contrib-type="author" id="aut0010"><name><surname>Nair</surname><given-names>S. Chandrasekhar</given-names></name></contrib><contrib contrib-type="author" id="aut0015"><name><surname>Hashmey</surname><given-names>R.</given-names></name></contrib></contrib-group><aff id="aff0005">Tawam hospital</aff><author-notes><corresp id="cor0005"><label>⁎</label>Corresponding author.</corresp></author-notes><pub-date pub-type="pmc-release"><day>8</day><month>1</month><year>2019</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on .</pmc-comment>
<pub-date pub-type="ppub" iso-8601-date="2019-02-01"><season>January-February</season><year>2019</year></pub-date><pub-date pub-type="epub"><day>8</day><month>1</month><year>2019</year></pub-date><volume>12</volume><issue>1</issue><fpage>137</fpage><lpage>137</lpage><permissions><copyright-statement>Copyright © 2018 Published by Elsevier Ltd.</copyright-statement><copyright-year>2018</copyright-year><copyright-holder></copyright-holder><license><license-p>Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.</license-p></license></permissions></article-meta></front><body><p id="par0005"><bold>Introduction:</bold> MERS-CoV was first identified in 2012 and highest incidence was in Saudi Arabia, followed by Republic of Korea and UAE. The majority of reported cases are males. Patients with comorbidities have higher mortality rate. The source of MERS-CoV infection is linked to camel exposure, nosocomial and human-to-human transmission. The clinical course of MERS-CoV infection can vary from asymptomatic disease to septic shock with multi-organ failure (MOF). We studied the clinical characteristics and outcomes of MERS-CoV infected patients in AlAin – UAE.</p><p id="par0010"><bold>Method:</bold> A retrospective multicenter chart review study for MERS-CoV confirmed cases by RT-PCR at Tawam and AlAin Hospitals over 6 years period (2012 – 7/ 2018). Epidemiological, demographic, clinical and laboratory data were collected and analyzed using descriptive analysis.</p><p id="par0015"><bold>Results:</bold> A total of 58 individuals were identified, 41 males (70.6%) with median age of 43.5 years. The majority of patients were asymptomatic carriers or having mild symptoms (34 [58%]) and were previously healthy. The comorbid conditions were hypertension (18[31%]), diabetes mellitus (11[18.9%]), coronary artery disease (6[10.3%]), and chronic kidney disease (9 [15.5%]). The risk factors for MERS-CoV infection were camels contact (5[8.6%]), travel 5 [8.6%](Oman 2, Saudi Arabia 3) and human-to-human contact with MERS-CoV infected patient or nosocomial transmissions (40 [68.9%]). Common symptoms at presentation were fever 46.5%, myalgia 41.3%, respiratory symptoms 41.3%, and gastrointestinal symptoms 22.4%. The mean duration of viral shedding was 18.5 days. Twelve patients (20.6%) required ICU care for septic shock, acute respiratory failure and acute kidney injury (AKI) requiring renal replacement therapy. The mortality rate was 12% and only noted among ICU admitted cases.</p><p id="par0020"><bold>Conclusion:</bold> In this study of MERS-CoV, human-to-human and nosocomial transmissions were more common than camel contact. In keeping with previous studies, most patients had mild symptoms, however, the mortality rate among adult ICU admissions was high (12%).</p></body></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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